Mono can be diagnosed by the ways of medical history given by the patient, and the physical examination which is done. This is known as a “clinical diagnosis”, and here doctor generally does not need a wide variety of expensive.
Doctor will look at the symptoms and the age of the patient because people infected with EBV are more likely to develop mono if they are a teenager or young adult.
A physical evaluation is made based on the symptoms and possible exposure to the disease by asking questions and by examining signs of the infection such as looking at the back of the throat, listen to the lungs and checking the skin and pressing on abdomen.
A doctor examines enlarged lymph nodes. The spleen often is enlarged during mono infections, although this can be difficult to determine without testing – unless the enlargement is significant.
If a doctor is unsure of the diagnosis of mono through clinical diagnosis, there are some basic blood tests available such as:
A Monospot Test involves a blood test. Blood will be analyzed in a laboratory for antibodies. Antibodies are a specific component of immune system that fights against infection. If body detects EBV, it can develop a type of antibody called Heterophile Antibodies. If Heterophile Antibodies in blood. Then mono spot test is “positive.” A positive mono spot test accompanied by the mono symptoms results in a diagnosis of infectious mono. However, mono spot tests can be false-positive, about 10-15% of the time.
It is possible for the Monospot Test to come back negative early in the course of the infection (False negative). If the mononucleosis test is negative, your doctor may test for an infection with Cytomegalo Virus (CMV) or other organisms. CMV can cause a mono-like illness.
If mono spot test is negative but the patient have all the symptoms of mono, more testing will be needed to make a diagnosis.
Complete Blood Count Test (CBC) may be done to rule out other infections or complications of mono.
Liver Test may be done to find out whether the virus has affected the liver. A blood chemistry test may reveal abnormalities in liver function.