Megaloblastic Anemia – Symptoms

Megaloblastic type of anemia occurs due to vitamin B 12 or folic acid deficiency. Some types are the result of problems in the bone marrow where blood cells are produced. Red blood cell production may be reduced or affected by chemicals or viruses that attack the bone marrow. The goal of treatment is to determine the cause of anemia and treatment depends on the cause. Anemia’s related to vitamin deficiencies are discussed separately.

Diseases of the small intestine causing malabsorption can cause vitamin B12 deficiency. Vegans (people who eat absolutely no animal foods) are at risk of inadequate vitamin B12 because of this vitamin in their diet. But it takes a long time to exhaust all the vitamin B12 is stored in the liver. There is a congenital form of pernicious anemia due to a defect of intrinsic factor in the birth that is clearly inherited as an autosomal recessive trait with the affected child having received two copies of the gene, one from each parent. Vitamin B12 helps in the process of contraction. Without vitamin B12, there are not enough red blood cells, and those in circulation are large and quickly damaged. This leads to anemia, which means that there is a deficiency of normal red cells. Symptoms, which usually start gradually, include loss of appetite, diarrhea, pallor, fatigue and headache. Tingling in hands and feet as well as the appearance of spastic movements, may indicate that the nervous system is affected. The word “pernicious” is highly injurious, destructive or deadly.

“Megaloblastic anemia is an anemia that results from inhibition of DNA synthesis in red blood cell production. When DNA synthesis is impaired, the cell cycle cannot progress from the G2 growth stage to the mitosis (M) stage. This leads to continuing cell growth without division, which presents as macrocytosis”.


There are many factors affecting this disease, so in this article we going to mention some of them. The B12 vitamin deficiencies impair the normal function of DNA and can cause numerous abnormalities of the blood, the brain, and the nervous system.

Some common symptoms are as follows:

Painful tingling of the hands and feet

  • Weakness
  • Loss of coordination
  • Irritability and mental status changes
  • Gastrointestinal problems (e.g., diarrhea)
  • Decreased appetite
  • Changes of taste perception
  • Weight loss
  • Change in skin color
  • Headaches
  • Loss of appetite
  • Pale skin color
  • Sore mouth and tongue
  • Tingling and numbness of hands and feet
  • Tiredness