TSH or Thyroid Stimulating Hormone is produced by the pituitary gland of the human body. This hormone helps in the stimulation of the thyroid gland so that it can produce thyroid hormones like T3 & T4. In the absence of TSH, the thyroid gland may reduce the production of the thyroid hormones resulting in many thyroid related disorders in the body. In certain scenarios when the thyroid gland has reduced the production of T3 and t$ hormones, the pituitary gland increases the production of TSH so that these hormones can stimulate the thyroid and help in resuming the production of thyroid hormones. However, sometimes the pituitary gland may not produce sufficient amount of TSH, which is when different thyroid disorders occur.
Measurement of Pituitary Production of TSH
It is an analysis that is done to measure the amount of hormone of pituitary origin present in the serum. Its determination serves to determine whether a thyroid problem is of primary origin (thyroid) or secondary origin (the hypothalamus).
Why This Analysis Is Done?
When thyroid hormone (T4 or T3) are low, the hypothalamus receives an order to produce more TSH, and thus be elevated to a primary thyroid problem.
If, however, because of hemorrhage, trauma or tumor hypothalamus can lower the secretion and therefore the thyroid is not stimulated and lower level of T3 and T4 are produced, resulting in a secondary goiter.
Their determination will help in administering treatment or hormonal regulator of thyroid function. If the TSH levels are normal then the treatment of the disease will focus on treating the thyroid gland, whereas if the TSH level is not normal then the treatment will focus on treating the pituitary gland.
This is why, this particular test is very important in the diagnosis and treatment of most thyroid related disorders.